..:::.. SBI FINE CHEMICALA INC. ..:::..

PICFTR & PICFTP technologies

Process Intensification and Continuous Reaction Technologies

SBI is a pioneer in process intensification and continuous reaction processing and their applications.

SBI proprietary Process Intensifying Continuous Flow-Through Reaction (PICFTR) reactor system allows rapid scale up of routine and highly energetic reactions and use of dangerous and sensitive chemicals such as Hydrazoic acid and organometallics etc., routinely and safely.

Following are some of the examples where our Process Intensifying Continuous process Flow Reactions can be applied to manufacture an array of advanced intermediates.

Fine chemical production, a critical stage of the pharmaceutical research, development, and manufacturing process, typically occurs in a batch environment. A superior alternative production methodology known as continuous processing technologies can reduce operating expenses by 90% and capital expenses by 50%.

SBI applies its revolutionary Process Intensifying Continuous Flow Reaction (PICFTR) and Processing (PICFTP) Technologies in the manufacturing of advanced pharmaceutical intermediates and fine chemicals.

Specially Designed Modular PICFTR Reactor System:

SBI's specially designed reactor system speeds up reactions by influencing reaction kinetics, thereby intensifying processing and cut down reaction time from hours to seconds. We design and develop special reactor and processing equipment to intensify reactions by influencing their reaction kinetics making them faster, safe, consistent in quality, reproducible and efficient.

Key Advantages

• Safe continuous production and handling of dangerous reagents such as diazomethane and hydrazoic acid etc.

• Safe handling of pressure and hydrogenation reactions in presence of homogeneous and heterogeneous catalysts.

• Possible to reduce number of steps.

• Improve quality, efficiency and reproducibility by reducing exposure of reagents and products to harsh reaction environment.

• Allows reaction monitoring on real time basis that provides absolute control on reaction parameters.

• Reduction or complete elimination of solvents.

• Minimize waste due to more selectivity and reduction of elimination of side reactions and by products.

Compared to traditional batch or continuous processing, SBI's PICFTR technology's extends following advantages:

Improved Kinetics: Reduces reaction time from hours to seconds by influencing reaction kinetics. SBI' designed proprietary PICFTR reactor system with superior mixing and heat exchange intensify reaction.

Handling of Energetic Exothermic Reactions: PICFTR can handle highly energetic reactions that are simply not possible on commercial scale in batch or even using other prevalent continuous processing technologies that are designed to accommodate only retention time.

Improved Quality and Yield: PICFTR technology allows the performing of larger volume reactions by rapid cycling of minute batches with a high degree of accuracy and reproducibility. PICFTR technology enables precise control on process parameters in real time. This is a significant improvement over standard batch reactions, where process parameters are hard to control due to large volumes involved. With precise control a reproducible consistency in quality is assured.

Increased Flexibility and Scalability: PICFTR technology enables greater flexibility in production run sizes, which can be changed without making any modification in design or equipment size, thereby maintaining strict process parameters without compromising on quality and yields. Hence, to increase production, only run time has to be increased and not the run size

Improved Safety and Environmental Impact: With the reduction in volumes of the reactants reacting at any given moment to almost miniscule levels, various risks that affect the scalability of some difficult reactions are virtually eliminated. This, in turn, reduces the risk of accidents by almost eliminating the problems that are related to the more common very large size batch reactions.

Reduced Costs: PICFTR provides several-fold cost reduction compared with current manufacturing techniques due to lower initial capital expenditures, the increase in quality of output, and process automation. In particular, the superior performance of CFTR technology allows operation at optimal reaction conditions, at higher concentrations or solvent less thereby minimizing raw materials wastage as well as the volumes of solvents and by-products that need to be handled or disposed off. Similarly, process automation results in increased efficiency and reduced labour costs.

Reduced Energy Consumption: PICFTR technology can operate with highly concentrated reactants that reduce energy consumption by up to 30%. In contrast, in batch production, a large amount of solvent has to be used to dilute the reactants, consequently requiring energy demanding evaporation.