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PICFTR & PICFTP technologies -Chemistry Capabilities |
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| SBI is capable of handling a variety of reaction conditions for example but not limited to conditions, reagents and reactions presented below. |
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Following are some of the examples where our Process Intensifying Continuous process Flow Reactions can be applied to manufacture an array of advanced intermediates. |
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Mitsunobu Reaction |
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With the Mitsunobu Reaction intermolecular substitution leads to esters, ethers, thioethers, isothiocyanates and amines. Via the intramolecular variant, lactones and lactames can be achieved. |
Application of Mitsunobu Reaction: Orlistat / Xanical: Anti-obesity (Hoffman La Roche); Eletriptan (Triptans): Migraine (Pfizer)
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Heck Reaction |
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Application of Heck Reaction: Eletriptan (Triptans): Migraine (Pfizer); Naratriptan : Migraine (Glaxo); Substituted Indoles
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| Suzuki Reaction |
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Application of Suzuki Reaction: Valsartan: Antihypertensive (Novartis); Boscalid: Fungicide (BASF); GR127935: Antihypertensive (Glaxo)
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| Asymmetric Hydrogenation |
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Application of Asymmetric Hydrogenation Reaction: Atrovastatin, Lipitor: Statin class; UK-396,082-03, Anti-thrombotic agent; Tipranavir: Anti-AIDS; drug (Pharmacia); levofloxacin: Anti-bacterial; L-Dopa Ant-Parkinson’s
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| Tryptamine Intermediates |
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Application of Typtamine Intermediates: Sumatryptan: Migraine; Melatonin; 5-Hydroxy tryptamine
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| Triphosgene Chemistry |
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Application of Triphosgene Chemistry: Carbonyl diimidazole: Coupling agent used in the synthesis of Viagra; Coupling agent in peptide synthesis (SBI proprietary technology); Oxacarbazepine: Anti-epileptic (Clariant); Droxicam: Anti-inflammatory |
| Hydrazoic Acid / Azide Chemistry |
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Lactic Acid Chemistry |
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| Malic acid Chemistry (combination of batch and continuous reactions) |
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Hydroxy Proline Chemistry |
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| Dehydration of Amides |
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Reactions involving Grignard reagents: |
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Application of Grignard Reagents: Voriconazole: Anti-fungal (Pfizer); Itraconazole: Anti-fungal;
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| Nitration |
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Knorr Pyrrole Synthesis |
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Pyrazole Synthesis |
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Oxazole Synthesis |
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Reactions with Acid Chlorides |
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